增长 激素 缺乏
Overview
增长 hormone deficiency is a condition that typically causes abnormally short height in children, although the 症状 vary depending on age. 激素, 也叫促生长激素, is produced by the pituitary gland, 位于大脑底部的.
The cause of the deficiency could be due to a number of reasons. It may exist at birth or develop after a head injury or medical condition that cause abnormal levels of hormones related to the endocrine glands. Cells in the pituitary gland that produce growth hormone are very sensitive to radiation and trauma. The condition can develop after radiation treatment for brain cancer or hormonal problems involving the pituitary gland or hypothalamus. 通常，无法确定原因.
Our approach to growth hormone deficiency
UCSF提供高度专业化的课程, world-class care for pituitary disorders, 比如生长激素缺乏. Our team includes experts in neuro内分泌学, neurosurgery and radiation therapy, 其他专业. We work together to help patients understand all aspects of their condition, so they can actively participate in decisions on their own care.
This condition is treated with growth hormone replacement therapy. Our goal is to improve our patients' overall sense of well-being and reverse 症状, such as 重量 gain and poor bone density.
奖 & 识别
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Among the top hospitals in the nation
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One of the nation's best for diabetes care & 内分泌学
迹象 & 症状
增长 hormone deficiency is most often diagnosed in children, rather than adults. Children with the condition have a slow rate of growth, usually less than 2 inches a year. In older children, the condition can result in delayed puberty or the absence of puberty.
成人的症状包括:
- 降低能源
- Increase in fat and decrease in lean muscle mass
- 困难锻炼
- 骨质疏松症
- 睡眠障碍
- Skin changes (fine lines, dryness, thinning)
- 心理症状, such as depression and feelings of social isolation, poor short-term memory and difficulty concentrating
诊断
来诊断病情, a physical exam and medical history will be performed to identify 症状. 在一个孩子身上, 重量, height and body proportions are measured to determine if there's a slow rate of growth.
In addition, the following tests may be performed:
- Blood tests to determine levels of hormones, including growth hormone and other endocrine hormones
- Bone mineral density scans to determine bone age and the development of osteoporosis, 常见症状
- Hand X-ray to identify bone age and possible osteoporosis
- Magnetic resonance imaging (MRI) of the head to determine other possible causes
治疗
合成生长激素, 每日注射, has proven to be an effective treatment of growth hormone deficiency. Treatment should be considered in the context of current 症状, lifestyle and risks.
In children, growth hormone replacement is critical for growth and development.
In adults, replacement therapy was controversial in the past but is now widely accepted.
Successful treatment with hormone replacement may depend on the patient's level of insulin-like growth factor 1 (IGF-1), which plays an important role in childhood growth. Its production is stimulated by growth hormone.
For patients with low levels of IGF-1, growth hormone levels can be adjusted to bring IGF-1 levels within a normal range. Benefits usually are noted in six to 18 months.
For patients with normal levels of IGF-1, there may be no benefit from growth hormone therapy.
加州大学旧金山分校健康 medical specialists have reviewed this information. It is for educational purposes only and is not intended to replace the advice of your doctor or other health care provider. We encourage you to discuss any questions or concerns you may have with your provider.
